Organic mercury compounds.



MAX ENG-ELMANN, OF

' \VGRM. reruns. BAYER & 00., or ELBERFELID, GERIVL'ANY,

GERMANY.

No Drawing.

T all whom it may concern Be it known that 1, Max ENGELMANN,

doctor of philosophy, chemist, citizen of the German Empire, residing atElberield, Gen

have invented new and usefullnr iany,

proven'ients in Organic Mercury Compounds, of which the following is aspecihcation.

My invention relates to the preparation of the hitherto unknown mercurycompounds of aryloxy substituted fatty acids which have in the shape oftheir anhydrids most probably the formula:

HgO R ounce (It standing for an aromatic radical, R for a hydrocarbonradical).

For producing the new products the aryloxy fatty acids are heated withmercuric oXid or salts of mercury. v

The new products are whitish compounds which are insoluble in water,alcohol, ether and benzene, soluble in dilute alkalis. They have provedto be valuable anti-syphilitics characterized by a mild action and thefact that they are non-irritant and not corrosive renders them highlyvaluable for internal application especially for subcutaneous in-,jection They have also proved to be valuable "disinfecting agentspossessing great disinfecting power. The"; can also be used in the shapeof their soluble compounds which can be obtained by treating the newproducts with alkalis, alkaline salts of amino fatty acids, alkali andsuch nitrogen compounds as are neutral to litmus and possess at the sametime a basic and acid character, alkali and-an imino compound, suchcaustic soda lye, ammonia, amins,'alanin, diethylbarbit'uric acid, urea,albumoses, acid amids, acid imids, caliein, polypeptids, etc. in orderto illustrate the new process more fully the following example is given,theparts being by weightz-20 parts of mercuric oxidare dissolved m 2500parts of a 10 per cent. sulfuric acid, 200 parts oforthoi'zhloronhenoxy-acetic acid are added and the mixture is heated to70 90" C. during Specification of Letters Patent.

ELBERFELD, GERMANY, ASSIGNOR TO FARBENFABRIKEN A COREORATION OF QBGANIC'MERCURY COMPOUNDS.

Patented (let. 3', 15 13,.

Application filed February 26, 1913. Serial No. 750,877.

2 hours. The resultingoily-mercuric--orthochloro-phenoXy-acetic-acid-anhydrid separates whichpurified by resolution from highly dilute caustic soda lye andprecipitation with carbonic acid. it is, a whitish crystalline compoundhaving no melting point, insoluble in water, alcohol, ether, ben- Zene,soluble in caustic 'alkalis, sodium carbonate and ammonia. It has mostprobably the formula the formula a oncoo (R standing for an aromaticradical, ll" tor a hydrocarbon radical) Which products are whitishcompounds insoluble in water. aicohol, ether and benzene, soluble indilute alkalis; yielding soluble compounds with alkali and ,z'iitrogencompounds, and being valuable therapeutics, substantially as de scribed.

2. As a. new product the new mercury compound derivable fronrortho-chioro phenoXy-acetic acid, which new product has in the shape ofits anhydrid most probably the formula:

-HgO\ which is a whitish crystalline compound.

having no meltis'lg point; insoluble in water, my hand i1 1 the alcoholother, benzene, soluble in" caustic Witnesses. 4 v alkalis, sodiumcarbolmto ancl' ammonia; E E N a] yielding solublec ompouncls withalkali and f "f -nitrogen compounds; and being a valuable W'itnessesQtherapeutic, substantially as described. HELEN; NUIEER,

In testimony whem'of I have hereunto ALBERT No -E3.

prgsehc e of two SUbSCllllJlIlg

